The widespread use of spectral domain-optical coherence tomography (SD-OCT) enables the evaluation of the GCIPL thickness and provides important information about the role of the inner retinal layer in human myopia. found that the change in asymmetry was obvious in the GCL and neural retina in myopic children, but they were unable to determine the change in the GCIPL in different sectors and whether the change in asymmetry contributes to myopia. It has proven to be a good diagnostic indicator of retinal ganglion cell damage or loss and can be used for early detection of glaucoma. The macular ganglion cell–inner plexiform layer (GCIPL) thickness, the combination of the thickness of the ganglion cell layer (GCL) and the inner plexiform layer, is less influenced by variations of the retinal nerve fibre layer thickness than by the ganglion cell complex thickness. Recent interest has focused on the structure of the retinal layer in the pathophysiology of myopia. Longer axial length (AL), and thinning of the retina and choroid are thought to be the key processes involved in the development of myopia. It is estimated that by 2050 the prevalence of myopia worldwide will reach 50% and high myopia may reach 10%. In a population of Chinese college students, its prevalence ran as high as 95.5%. The prevalence of myopia has increased rapidly in the Asian population in recent decades, especially among young adults. High myopia or pathologic myopia is associated with a progressive elongation of the globe which may result in many fundal changes and lead to visual impairment. Decreasing GCIPL thickness may be associated with the progression of myopia. In a specific Chinese young population, myopic eyes have measurably less macular GCIPL thickness than normal eyes. When adjusting for AL, IOP, and anterior chamber depth (ACD) in the myopia subgroup, the GCIPL thickness remained positively associated. The mean subfoveal CT also showed a significant difference between myopes and emmetropes, with 330.57 ± 9.43 μm for emmetropic groups and 265.98 ± 4.12 μm for myopic groups. The GCIPL thickness was significantly thinner in myopia than in emmetropia at all locations ( P < 0.05), affirming that myopia was associated with thinner GCIPL thickness ( P = 0.001). Average GCIPL thickness showed a significant difference between myopes and emmetropes, with 87.89 ± 3.65 μm for emmetropic groups and 82.65 ± 4.96 μm for myopic groups. ResultsĪ total of 348 eyes were included in the analysis. Subfoveal choroidal thickness (CT), axial length (AL), and spherical equivalents (SE) were also measured. SD-OCT was used to measure average and minimum GCIPL thickness, and GCIPL thickness at all sectors. In this study, we included Chinese young adults who underwent Cirrus spectral domain-optical coherence tomography (SD-OCT). To describe the distribution of ganglion cell–inner plexiform layer (GCIPL) thickness among Chinese young adults and report whether the decreased GCIPL thickness is associated with myopia.

Plexiform layers